Drug interactions
Diazepam intranasal + Propofol
Severity: Major
Diazepam intranasal and Propofol: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propofol and diazepam both depress the central nervous system, so sedation, respiratory depression and hypotension are additive. A minor pharmacokinetic effect on diazepam clearance has been suggested but the pharmacodynamic effect is the main concern.
What this interaction means in plain words
Diazepam intranasal and Propofol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive GABA-A receptor-mediated CNS depression; propofol may weakly inhibit CYP2C19-mediated diazepam metabolism.
What to do
Reduce the propofol dose and titrate slowly in patients who have received diazepam. Monitor oxygen saturation, ventilation and blood pressure until recovery.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Propofol
Frequently asked questions
Can I take Diazepam intranasal with Propofol?
MediHelp rates the interaction as major. Diazepam intranasal and Propofol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Propofol and diazepam both depress the central nervous system, so sedation, respiratory depression and hypotension are additive. A minor pharmacokinetic effect on diazepam clearance has been suggested but the pharmacodynamic effect is the main concern.
How serious is the interaction between Diazepam intranasal and Propofol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the propofol dose and titrate slowly in patients who have received diazepam. Monitor oxygen saturation, ventilation and blood pressure until recovery.
What other medicines interact with Propofol?
MediHelp also lists interactions of Propofol with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Propofol page.
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