Drug interactions
Diazepam intranasal + Ticlopidine
Severity: Moderate
Diazepam intranasal and Ticlopidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ticlopidine inhibits CYP2C19, which contributes to diazepam metabolism, so diazepam exposure and sedation may increase. Respiratory depression is possible, especially with other CNS depressants.
What this interaction means in plain words
Diazepam intranasal and Ticlopidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Ticlopidine inhibition of CYP2C19 reduces diazepam clearance.
What to do
Monitor for excessive sedation and respiratory depression, and use the lowest effective diazepam dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ticlopidine
Frequently asked questions
Can I take Diazepam intranasal with Ticlopidine?
MediHelp rates the interaction as moderate. Diazepam intranasal and Ticlopidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ticlopidine inhibits CYP2C19, which contributes to diazepam metabolism, so diazepam exposure and sedation may increase. Respiratory depression is possible, especially with other CNS depressants.
How serious is the interaction between Diazepam intranasal and Ticlopidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and respiratory depression, and use the lowest effective diazepam dose.
What other medicines interact with Ticlopidine?
MediHelp also lists interactions of Ticlopidine with, for example, Mavacamten, Abrocitinib, Acetylsalicylic acid. The full list is on the Ticlopidine page.
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