Drug interactions
Diazepam intranasal + Vilazodone
Severity: Moderate
Diazepam intranasal and Vilazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diazepam is a benzodiazepine with significant CNS depressant effects, and vilazodone can cause drowsiness and impaired psychomotor performance. Combined use may produce additive sedation and impaired coordination.
What this interaction means in plain words
Diazepam intranasal and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression via pharmacodynamic synergism.
What to do
Monitor for excessive sedation and advise against driving or operating machinery until response is known. Avoid alcohol and other sedatives.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vilazodone
- Isocarboxazid + Vilazodone Contraindicated
- Methylene blue + Vilazodone Contraindicated
- Phenelzine + Vilazodone Contraindicated
- Rasagiline + Vilazodone Contraindicated
- Selegiline transdermal + Vilazodone Contraindicated
- Selegiline + Vilazodone Contraindicated
Frequently asked questions
Can I take Diazepam intranasal with Vilazodone?
MediHelp rates the interaction as moderate. Diazepam intranasal and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diazepam is a benzodiazepine with significant CNS depressant effects, and vilazodone can cause drowsiness and impaired psychomotor performance. Combined use may produce additive sedation and impaired coordination.
How serious is the interaction between Diazepam intranasal and Vilazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and advise against driving or operating machinery until response is known. Avoid alcohol and other sedatives.
What other medicines interact with Vilazodone?
MediHelp also lists interactions of Vilazodone with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Vilazodone page.
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