Drug interactions
Diazoxide + Hydrochlorothiazide-lisinopril
Severity: Moderate
Diazoxide and Hydrochlorothiazide-lisinopril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazides and oral diazoxide both raise blood glucose, and diazoxide also has hypotensive and sodium-retaining properties. Combined use can worsen hyperglycemia, hyperuricemia and hypotension. The thiazide is also used to counter diazoxide-related fluid retention, so the pairing is sometimes deliberate.
What this interaction means in plain words
Diazoxide and Hydrochlorothiazide-lisinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diazoxide belongs to Miscellaneous; Hydrochlorothiazide-lisinopril belongs to Cardiovascular.
Why it happens
Additive hyperglycemic effects (diazoxide suppresses insulin secretion via K-ATP channel opening; thiazides impair glucose tolerance) plus additive vasodilatory and hypotensive effects.
What to do
Monitor blood glucose, blood pressure and electrolytes, particularly when starting or changing doses. Adjust diazoxide or antidiabetic therapy as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Other interactions of Diazoxide
Frequently asked questions
Can I take Diazoxide with Hydrochlorothiazide-lisinopril?
MediHelp rates the interaction as moderate. Diazoxide and Hydrochlorothiazide-lisinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazides and oral diazoxide both raise blood glucose, and diazoxide also has hypotensive and sodium-retaining properties. Combined use can worsen hyperglycemia, hyperuricemia and hypotension. The thiazide is also used to counter diazoxide-related fluid retention, so the pairing is sometimes deliberate.
How serious is the interaction between Diazoxide and Hydrochlorothiazide-lisinopril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose, blood pressure and electrolytes, particularly when starting or changing doses. Adjust diazoxide or antidiabetic therapy as needed.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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