Drug interactions
Dichloralphenazone + Metoclopramide
Severity: Moderate
Dichloralphenazone and Metoclopramide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dichloralphenazone is a sedative-hypnotic that releases chloral hydrate, and combining it with metoclopramide may add to sedation and psychomotor impairment. The effect is generally manageable with monitoring.
What this interaction means in plain words
Dichloralphenazone and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant effects.
What to do
Monitor for excessive sedation and use the lowest effective doses. Advise the patient to avoid alcohol and driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoclopramide
Frequently asked questions
Can I take Dichloralphenazone with Metoclopramide?
MediHelp rates the interaction as moderate. Dichloralphenazone and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dichloralphenazone is a sedative-hypnotic that releases chloral hydrate, and combining it with metoclopramide may add to sedation and psychomotor impairment. The effect is generally manageable with monitoring.
How serious is the interaction between Dichloralphenazone and Metoclopramide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and use the lowest effective doses. Advise the patient to avoid alcohol and driving.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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