Drug interactions
Dichlorphenamide + Disopyramide
Severity: Moderate
Dichlorphenamide and Disopyramide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hypokalemia from dichlorphenamide may increase the proarrhythmic and QT-prolonging risk of disopyramide. Disopyramide itself is not a major potassium-lowering drug, but its safety depends on normal electrolytes.
What this interaction means in plain words
Dichlorphenamide and Disopyramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dichlorphenamide belongs to Miscellaneous; Disopyramide belongs to Cardiovascular.
Why it happens
Dichlorphenamide-induced hypokalemia potentiates QT prolongation and torsades risk of disopyramide.
What to do
Monitor serum potassium and ECG QT interval, and correct hypokalemia before and during therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dichlorphenamide and Disopyramide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Dichlorphenamide
Other interactions of Disopyramide
- Amisulpride + Disopyramide Contraindicated
- Desipramine + Disopyramide Contraindicated
- Disopyramide + Dronedarone Contraindicated
- Disopyramide + Itraconazole Contraindicated
- Disopyramide + Ketoconazole Contraindicated
- Disopyramide + Maprotiline Contraindicated
Frequently asked questions
Can I take Dichlorphenamide with Disopyramide?
MediHelp rates the interaction as moderate. Dichlorphenamide and Disopyramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hypokalemia from dichlorphenamide may increase the proarrhythmic and QT-prolonging risk of disopyramide. Disopyramide itself is not a major potassium-lowering drug, but its safety depends on normal electrolytes.
How serious is the interaction between Dichlorphenamide and Disopyramide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and ECG QT interval, and correct hypokalemia before and during therapy.
What other medicines interact with Dichlorphenamide?
MediHelp also lists interactions of Dichlorphenamide with, for example, Acetazolamide, Acetylsalicylic acid, Ammonium chloride. The full list is on the Dichlorphenamide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
