Drug interactions
Dichlorphenamide + Propofol
Severity: Moderate
Dichlorphenamide and Propofol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dichlorphenamide, a carbonic anhydrase inhibitor, causes hyperchloremic metabolic acidosis. Propofol, especially with prolonged high-dose infusion, can rarely cause metabolic acidosis, so acid-base disturbance could be compounded.
What this interaction means in plain words
Dichlorphenamide and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dichlorphenamide belongs to Miscellaneous; Propofol belongs to Central Nervous System.
Why it happens
Additive metabolic acidosis from carbonic anhydrase inhibition (bicarbonate loss) and propofol-related metabolic effects.
What to do
Check serum bicarbonate and acid-base status before and during prolonged propofol infusion in patients taking dichlorphenamide. Correct acidosis and reconsider the sedative if bicarbonate falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propofol
Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Dichlorphenamide with Propofol?
MediHelp rates the interaction as moderate. Dichlorphenamide and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dichlorphenamide, a carbonic anhydrase inhibitor, causes hyperchloremic metabolic acidosis. Propofol, especially with prolonged high-dose infusion, can rarely cause metabolic acidosis, so acid-base disturbance could be compounded.
How serious is the interaction between Dichlorphenamide and Propofol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum bicarbonate and acid-base status before and during prolonged propofol infusion in patients taking dichlorphenamide. Correct acidosis and reconsider the sedative if bicarbonate falls.
What other medicines interact with Propofol?
MediHelp also lists interactions of Propofol with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Propofol page.
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