Drug interactions
Diclofenac + Ephedrine
Severity: Minor
Diclofenac and Ephedrine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may raise blood pressure and ephedrine is a sympathomimetic that also raises blood pressure, so effects may be additive. The interaction is generally modest and clinical data are limited.
What this interaction means in plain words
Diclofenac and Ephedrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Diclofenac belongs to Musculoskeletal; Ephedrine belongs to Cardiovascular.
Why it happens
Additive pressor effects; NSAIDs cause sodium and fluid retention while ephedrine stimulates adrenergic receptors.
What to do
Monitor blood pressure in patients with hypertension or cardiovascular disease when both are used together.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Other interactions of Ephedrine
- Ephedrine + Isocarboxazid Contraindicated
- Ephedrine + Phenelzine Contraindicated
- Ephedrine + Procarbazine Contraindicated
- Ephedrine + Rasagiline Contraindicated
- Ephedrine + Selegiline Contraindicated
- Ephedrine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Diclofenac with Ephedrine?
MediHelp rates the interaction as minor. Diclofenac and Ephedrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. NSAIDs may raise blood pressure and ephedrine is a sympathomimetic that also raises blood pressure, so effects may be additive. The interaction is generally modest and clinical data are limited.
How serious is the interaction between Diclofenac and Ephedrine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure in patients with hypertension or cardiovascular disease when both are used together.
What other medicines interact with Diclofenac?
MediHelp also lists interactions of Diclofenac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Diclofenac page.
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