Drug interactions
Diclofenac + Eplerenone
Severity: Moderate
Diclofenac and Eplerenone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diclofenac may reduce the antihypertensive effect of eplerenone and, together, increase the risk of hyperkalemia and renal impairment. The risk is greatest in older, volume-depleted or renally impaired patients.
What this interaction means in plain words
Diclofenac and Eplerenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diclofenac belongs to Musculoskeletal; Eplerenone belongs to Cardiovascular.
Why it happens
NSAID inhibition of renal prostaglandin synthesis causes sodium retention and reduced renal perfusion, opposing eplerenone and adding to potassium retention.
What to do
Monitor blood pressure, serum potassium and creatinine after starting and during combined use. Use the lowest NSAID dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Other interactions of Eplerenone
- Amiloride + Eplerenone Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Clarithromycin + Eplerenone Contraindicated
- Cobicistat + Eplerenone Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Eplerenone Contraindicated
- Ensitrelvir + Eplerenone Contraindicated
Frequently asked questions
Can I take Diclofenac with Eplerenone?
MediHelp rates the interaction as moderate. Diclofenac and Eplerenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diclofenac may reduce the antihypertensive effect of eplerenone and, together, increase the risk of hyperkalemia and renal impairment. The risk is greatest in older, volume-depleted or renally impaired patients.
How serious is the interaction between Diclofenac and Eplerenone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum potassium and creatinine after starting and during combined use. Use the lowest NSAID dose for the shortest time.
What other medicines interact with Diclofenac?
MediHelp also lists interactions of Diclofenac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Diclofenac page.
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