Drug interactions
Diclofenac + Etravirine
Severity: Minor
Diclofenac and Etravirine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etravirine inhibits CYP2C9 and may increase exposure to CYP2C9 substrates like diclofenac, although it also induces CYP3A4. Higher diclofenac exposure could raise the risk of NSAID toxicity.
What this interaction means in plain words
Diclofenac and Etravirine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Diclofenac belongs to Musculoskeletal; Etravirine belongs to Anti Virals.
Why it happens
Etravirine inhibits CYP2C9, reducing diclofenac metabolism.
What to do
Use the lowest effective diclofenac dose and monitor for GI and renal adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Diclofenac with Etravirine?
MediHelp rates the interaction as minor. Diclofenac and Etravirine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Etravirine inhibits CYP2C9 and may increase exposure to CYP2C9 substrates like diclofenac, although it also induces CYP3A4. Higher diclofenac exposure could raise the risk of NSAID toxicity.
How serious is the interaction between Diclofenac and Etravirine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective diclofenac dose and monitor for GI and renal adverse effects.
What other medicines interact with Diclofenac?
MediHelp also lists interactions of Diclofenac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Diclofenac page.
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