Drug interactions
Diclofenac + Fluvoxamine
Severity: Moderate
Diclofenac and Fluvoxamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluvoxamine reduces platelet serotonin uptake, and with diclofenac the risk of upper gastrointestinal bleeding is increased. Fluvoxamine also inhibits CYP2C9, which may raise diclofenac levels.
What this interaction means in plain words
Diclofenac and Fluvoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diclofenac belongs to Musculoskeletal; Fluvoxamine belongs to Central Nervous System.
Why it happens
Additive impairment of platelet function and mucosal protection, with possible CYP2C9 inhibition by fluvoxamine.
What to do
Use the lowest effective diclofenac dose for the shortest duration and consider gastroprotection with a proton pump inhibitor. Monitor for signs of GI bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Frequently asked questions
Can I take Diclofenac with Fluvoxamine?
MediHelp rates the interaction as moderate. Diclofenac and Fluvoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluvoxamine reduces platelet serotonin uptake, and with diclofenac the risk of upper gastrointestinal bleeding is increased. Fluvoxamine also inhibits CYP2C9, which may raise diclofenac levels.
How serious is the interaction between Diclofenac and Fluvoxamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective diclofenac dose for the shortest duration and consider gastroprotection with a proton pump inhibitor. Monitor for signs of GI bleeding.
What other medicines interact with Diclofenac?
MediHelp also lists interactions of Diclofenac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Diclofenac page.
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