Drug interactions
Diclofenac + Fondaparinux
Severity: Major
Diclofenac and Fondaparinux: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diclofenac inhibits platelet function and can cause GI ulceration, and fondaparinux is a factor Xa-mediated anticoagulant. Together they raise the risk of significant bleeding.
What this interaction means in plain words
Diclofenac and Fondaparinux can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Diclofenac belongs to Musculoskeletal; Fondaparinux belongs to Cardiovascular.
Why it happens
Additive hemostatic impairment from NSAID platelet inhibition and indirect factor Xa inhibition via antithrombin.
What to do
Avoid concomitant NSAIDs where possible; if unavoidable, use the lowest effective dose briefly and monitor for bleeding and hemoglobin.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Other interactions of Fondaparinux
- Defibrotide + Fondaparinux Contraindicated
- Fondaparinux + Ketorolac Contraindicated
- Abciximab + Fondaparinux Major
- Aceclofenac + Fondaparinux Major
- Acetylsalicylic acid + Fondaparinux Major
- Alteplase + Fondaparinux Major
Frequently asked questions
Can I take Diclofenac with Fondaparinux?
MediHelp rates the interaction as major. Diclofenac and Fondaparinux can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Diclofenac inhibits platelet function and can cause GI ulceration, and fondaparinux is a factor Xa-mediated anticoagulant. Together they raise the risk of significant bleeding.
How serious is the interaction between Diclofenac and Fondaparinux?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant NSAIDs where possible; if unavoidable, use the lowest effective dose briefly and monitor for bleeding and hemoglobin.
What other medicines interact with Diclofenac?
MediHelp also lists interactions of Diclofenac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Diclofenac page.
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