Drug interactions
Diclofenac + Furosemide
Severity: Moderate
Diclofenac and Furosemide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diclofenac can reduce the diuretic and antihypertensive effects of furosemide by causing sodium and water retention. In volume-depleted patients the combination also raises the risk of acute kidney injury.
What this interaction means in plain words
Diclofenac and Furosemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diclofenac belongs to Musculoskeletal; Furosemide belongs to Cardiovascular.
Why it happens
NSAID inhibition of renal prostaglandins reduces renal blood flow and blunts loop diuretic natriuresis.
What to do
Monitor diuretic response, weight, blood pressure and serum creatinine. Avoid dehydration and consider an alternative analgesic in heart failure or renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Frequently asked questions
Can I take Diclofenac with Furosemide?
MediHelp rates the interaction as moderate. Diclofenac and Furosemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diclofenac can reduce the diuretic and antihypertensive effects of furosemide by causing sodium and water retention. In volume-depleted patients the combination also raises the risk of acute kidney injury.
How serious is the interaction between Diclofenac and Furosemide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor diuretic response, weight, blood pressure and serum creatinine. Avoid dehydration and consider an alternative analgesic in heart failure or renal impairment.
What other medicines interact with Diclofenac?
MediHelp also lists interactions of Diclofenac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Diclofenac page.
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