Drug interactions
Diclofenac + Gemifloxacin
Severity: Moderate
Diclofenac and Gemifloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs given with fluoroquinolones may lower the seizure threshold and raise the chance of CNS stimulation or convulsions. The risk is greatest in patients with epilepsy, prior seizures, renal impairment or high fluoroquinolone exposure.
What this interaction means in plain words
Diclofenac and Gemifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diclofenac belongs to Musculoskeletal; Gemifloxacin belongs to Anti Bacterial.
Why it happens
Fluoroquinolones inhibit GABA-A receptor binding and NSAIDs may potentiate this effect, producing additive CNS excitation.
What to do
Avoid the combination in patients with a seizure history or other predisposing factors. Otherwise monitor for tremor, agitation or seizures and prefer a non-NSAID analgesic if risk is high.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Other interactions of Gemifloxacin
- Arsenic trioxide + Gemifloxacin Contraindicated
- Dofetilide + Gemifloxacin Contraindicated
- Gemifloxacin + Ibutilide Contraindicated
- Gemifloxacin + Pimozide Contraindicated
- Gemifloxacin + Thioridazine Contraindicated
- Gemifloxacin + Vandetanib Contraindicated
Frequently asked questions
Can I take Diclofenac with Gemifloxacin?
MediHelp rates the interaction as moderate. Diclofenac and Gemifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs given with fluoroquinolones may lower the seizure threshold and raise the chance of CNS stimulation or convulsions. The risk is greatest in patients with epilepsy, prior seizures, renal impairment or high fluoroquinolone exposure.
How serious is the interaction between Diclofenac and Gemifloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in patients with a seizure history or other predisposing factors. Otherwise monitor for tremor, agitation or seizures and prefer a non-NSAID analgesic if risk is high.
What other medicines interact with Diclofenac?
MediHelp also lists interactions of Diclofenac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Diclofenac page.
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