Drug interactions
Diclofenac + Imidapril
Severity: Moderate
Diclofenac and Imidapril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diclofenac can weaken the blood-pressure-lowering effect of imidapril and, in combination, raises the risk of acute kidney injury and hyperkalemia. Risk is highest in older people, those who are volume depleted or with existing renal disease.
What this interaction means in plain words
Diclofenac and Imidapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diclofenac belongs to Musculoskeletal; Imidapril belongs to Cardiovascular.
Why it happens
NSAIDs inhibit vasodilatory renal prostaglandins and cause sodium retention, opposing ACE inhibitor effects and reducing glomerular perfusion.
What to do
Monitor blood pressure, creatinine and potassium, especially at initiation. Maintain hydration and limit NSAID dose and duration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Other interactions of Imidapril
- Amiloride + Imidapril Major
- Eplerenone + Imidapril Major
- Imidapril + Lithium Major
- Imidapril + Pregabalin Major
- Imidapril + Spironolactone Major
- Imidapril + Triamterene Major
Frequently asked questions
Can I take Diclofenac with Imidapril?
MediHelp rates the interaction as moderate. Diclofenac and Imidapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diclofenac can weaken the blood-pressure-lowering effect of imidapril and, in combination, raises the risk of acute kidney injury and hyperkalemia. Risk is highest in older people, those who are volume depleted or with existing renal disease.
How serious is the interaction between Diclofenac and Imidapril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, creatinine and potassium, especially at initiation. Maintain hydration and limit NSAID dose and duration.
What other medicines interact with Diclofenac?
MediHelp also lists interactions of Diclofenac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Diclofenac page.
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