Drug interactions
Diclofenac + Levomilnacipran
Severity: Moderate
Diclofenac and Levomilnacipran: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
SNRIs reduce platelet serotonin uptake and impair platelet aggregation, and combined with NSAIDs this raises the risk of bleeding, especially gastrointestinal bleeding.
What this interaction means in plain words
Diclofenac and Levomilnacipran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diclofenac belongs to Musculoskeletal; Levomilnacipran belongs to Central Nervous System.
Why it happens
Additive impairment of platelet function: serotonin reuptake inhibition plus NSAID cyclooxygenase inhibition, with added mucosal injury.
What to do
Monitor for signs of bleeding and consider gastroprotection with a proton pump inhibitor in patients at risk. Prefer non-NSAID analgesia when possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Other interactions of Levomilnacipran
- Isocarboxazid + Levomilnacipran Contraindicated
- Levomilnacipran + Linezolid Contraindicated
- Levomilnacipran + Methylthioninium chloride Contraindicated
- Levomilnacipran + Phenelzine Contraindicated
- Levomilnacipran + Procarbazine Contraindicated
- Levomilnacipran + Rasagiline Contraindicated
Frequently asked questions
Can I take Diclofenac with Levomilnacipran?
MediHelp rates the interaction as moderate. Diclofenac and Levomilnacipran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. SNRIs reduce platelet serotonin uptake and impair platelet aggregation, and combined with NSAIDs this raises the risk of bleeding, especially gastrointestinal bleeding.
How serious is the interaction between Diclofenac and Levomilnacipran?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of bleeding and consider gastroprotection with a proton pump inhibitor in patients at risk. Prefer non-NSAID analgesia when possible.
What other medicines interact with Diclofenac?
MediHelp also lists interactions of Diclofenac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Diclofenac page.
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