Drug interactions
Diclofenac + Lonafarnib
Severity: Minor
Diclofenac and Lonafarnib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lonafarnib is a sensitive CYP3A4 substrate. Diclofenac is at most a very weak CYP3A4 inhibitor, so any rise in lonafarnib exposure is likely small.
What this interaction means in plain words
Diclofenac and Lonafarnib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Diclofenac belongs to Musculoskeletal; Lonafarnib belongs to Miscellaneous.
Why it happens
Possible weak CYP3A4 inhibition reducing lonafarnib clearance.
What to do
No dose change is generally required; monitor for lonafarnib gastrointestinal toxicity and palpitations or syncope.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Diclofenac with Lonafarnib?
MediHelp rates the interaction as minor. Diclofenac and Lonafarnib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lonafarnib is a sensitive CYP3A4 substrate. Diclofenac is at most a very weak CYP3A4 inhibitor, so any rise in lonafarnib exposure is likely small.
How serious is the interaction between Diclofenac and Lonafarnib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally required; monitor for lonafarnib gastrointestinal toxicity and palpitations or syncope.
What other medicines interact with Diclofenac?
MediHelp also lists interactions of Diclofenac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Diclofenac page.
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