Drug interactions
Diclofenac + Lornoxicam
Severity: Major
Diclofenac and Lornoxicam: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining two NSAIDs adds no proven benefit and increases the risk of GI ulceration and bleeding, renal injury and cardiovascular events.
What this interaction means in plain words
Diclofenac and Lornoxicam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Diclofenac belongs to Musculoskeletal; Lornoxicam belongs to Musculoskeletal.
Why it happens
Additive inhibition of COX-1 and COX-2, reducing gastroprotective prostaglandins, platelet function and renal perfusion.
What to do
Avoid concurrent use of two systemic NSAIDs; use a single agent at the lowest effective dose, adding gastroprotection if risk factors exist.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Other interactions of Lornoxicam
Frequently asked questions
Can I take Diclofenac with Lornoxicam?
MediHelp rates the interaction as major. Diclofenac and Lornoxicam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining two NSAIDs adds no proven benefit and increases the risk of GI ulceration and bleeding, renal injury and cardiovascular events.
How serious is the interaction between Diclofenac and Lornoxicam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of two systemic NSAIDs; use a single agent at the lowest effective dose, adding gastroprotection if risk factors exist.
What other medicines interact with Diclofenac?
MediHelp also lists interactions of Diclofenac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Diclofenac page.
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