Drug interactions
Diclofenac + Losartan
Severity: Moderate
Diclofenac and Losartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diclofenac can reduce the antihypertensive effect of losartan and raises the risk of acute kidney injury, especially in elderly or volume-depleted patients. Hyperkalemia may also occur.
What this interaction means in plain words
Diclofenac and Losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diclofenac belongs to Musculoskeletal; Losartan belongs to Cardiovascular.
Why it happens
NSAIDs inhibit vasodilatory renal prostaglandins and cause sodium retention, reducing glomerular perfusion during angiotensin receptor blockade.
What to do
Monitor blood pressure, serum creatinine and potassium, particularly at initiation and in at-risk patients. Maintain hydration and limit NSAID duration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Frequently asked questions
Can I take Diclofenac with Losartan?
MediHelp rates the interaction as moderate. Diclofenac and Losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diclofenac can reduce the antihypertensive effect of losartan and raises the risk of acute kidney injury, especially in elderly or volume-depleted patients. Hyperkalemia may also occur.
How serious is the interaction between Diclofenac and Losartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium, particularly at initiation and in at-risk patients. Maintain hydration and limit NSAID duration.
What other medicines interact with Diclofenac?
MediHelp also lists interactions of Diclofenac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Diclofenac page.
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