Drug interactions
Diclofenac + Moxifloxacin
Severity: Moderate
Diclofenac and Moxifloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs combined with moxifloxacin may increase the likelihood of CNS stimulation and convulsions. The concern is mainly in patients with predisposing neurological conditions or high fluoroquinolone exposure.
What this interaction means in plain words
Diclofenac and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diclofenac belongs to Musculoskeletal; Moxifloxacin belongs to Anti Bacterial.
Why it happens
Fluoroquinolone GABA-A receptor antagonism may be potentiated by NSAIDs, lowering seizure threshold.
What to do
Avoid in patients with epilepsy or prior seizures. Otherwise monitor for agitation, tremor or seizures.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Diclofenac and Moxifloxacin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Frequently asked questions
Can I take Diclofenac with Moxifloxacin?
MediHelp rates the interaction as moderate. Diclofenac and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs combined with moxifloxacin may increase the likelihood of CNS stimulation and convulsions. The concern is mainly in patients with predisposing neurological conditions or high fluoroquinolone exposure.
How serious is the interaction between Diclofenac and Moxifloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in patients with epilepsy or prior seizures. Otherwise monitor for agitation, tremor or seizures.
What other medicines interact with Diclofenac?
MediHelp also lists interactions of Diclofenac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Diclofenac page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
