Drug interactions
Diclofenac + Nabumetone
Severity: Major
Diclofenac and Nabumetone: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Using two NSAIDs together provides no added benefit and increases the risk of GI ulceration and bleeding, renal injury and cardiovascular events.
What this interaction means in plain words
Diclofenac and Nabumetone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Diclofenac belongs to Musculoskeletal; Nabumetone belongs to Musculoskeletal.
Why it happens
Additive inhibition of COX-1 and COX-2, reducing gastroprotective prostaglandins, platelet function and renal perfusion.
What to do
Avoid combining NSAIDs; use a single agent at the lowest effective dose and consider gastroprotection if risk factors exist.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Other interactions of Nabumetone
- Ketorolac intranasal + Nabumetone Contraindicated
- Ketorolac + Nabumetone Contraindicated
- Aceclofenac + Nabumetone Major
- Acemetacin + Nabumetone Major
- Acetylsalicylic acid + Nabumetone Major
- Alteplase + Nabumetone Major
Frequently asked questions
Can I take Diclofenac with Nabumetone?
MediHelp rates the interaction as major. Diclofenac and Nabumetone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Using two NSAIDs together provides no added benefit and increases the risk of GI ulceration and bleeding, renal injury and cardiovascular events.
How serious is the interaction between Diclofenac and Nabumetone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining NSAIDs; use a single agent at the lowest effective dose and consider gastroprotection if risk factors exist.
What other medicines interact with Diclofenac?
MediHelp also lists interactions of Diclofenac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Diclofenac page.
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