Drug interactions
Diclofenac + Pegaspargase
Severity: Moderate
Diclofenac and Pegaspargase: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pegaspargase can cause coagulopathy and thrombocytopenia, and diclofenac inhibits platelet function and can injure the gastric mucosa. Together they raise the risk of bleeding events.
What this interaction means in plain words
Diclofenac and Pegaspargase can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diclofenac belongs to Musculoskeletal; Pegaspargase belongs to Oncology.
Why it happens
Additive effect of asparaginase-related coagulation factor deficiency and NSAID platelet inhibition.
What to do
Avoid NSAIDs when possible during pegaspargase therapy; if used, monitor platelets and coagulation parameters and watch for bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Other interactions of Pegaspargase
- Etodolac + Pegaspargase Major
- Ketorolac + Pegaspargase Major
- Mefenamic acid + Pegaspargase Major
- Acetylsalicylic acid + Pegaspargase Moderate
- Argatroban + Pegaspargase Moderate
- Celecoxib + Pegaspargase Moderate
Frequently asked questions
Can I take Diclofenac with Pegaspargase?
MediHelp rates the interaction as moderate. Diclofenac and Pegaspargase can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pegaspargase can cause coagulopathy and thrombocytopenia, and diclofenac inhibits platelet function and can injure the gastric mucosa. Together they raise the risk of bleeding events.
How serious is the interaction between Diclofenac and Pegaspargase?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid NSAIDs when possible during pegaspargase therapy; if used, monitor platelets and coagulation parameters and watch for bleeding.
What other medicines interact with Diclofenac?
MediHelp also lists interactions of Diclofenac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Diclofenac page.
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