Drug interactions
Diclofenac + Peginterferon alfa 2b
Severity: Minor
Diclofenac and Peginterferon alfa 2b: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Peginterferon alfa-2b may alter the metabolism of drugs cleared by CYP enzymes, and diclofenac is a CYP2C9 substrate. The clinical effect on diclofenac exposure is not well characterized and is probably small.
What this interaction means in plain words
Diclofenac and Peginterferon alfa 2b have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Diclofenac belongs to Musculoskeletal; Peginterferon alfa 2b belongs to Anti Virals.
Why it happens
Interferons can downregulate some hepatic CYP activity, but the effect on CYP2C9 is uncertain and not firmly established.
What to do
No routine dose change is needed; monitor for altered analgesic response or diclofenac adverse effects during interferon therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Other interactions of Peginterferon alfa 2b
Frequently asked questions
Can I take Diclofenac with Peginterferon alfa 2b?
MediHelp rates the interaction as minor. Diclofenac and Peginterferon alfa 2b have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Peginterferon alfa-2b may alter the metabolism of drugs cleared by CYP enzymes, and diclofenac is a CYP2C9 substrate. The clinical effect on diclofenac exposure is not well characterized and is probably small.
How serious is the interaction between Diclofenac and Peginterferon alfa 2b?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor for altered analgesic response or diclofenac adverse effects during interferon therapy.
What other medicines interact with Diclofenac?
MediHelp also lists interactions of Diclofenac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Diclofenac page.
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