Drug interactions
Diclofenac + Potassium iodide
Severity: Minor
Diclofenac and Potassium iodide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Potassium iodide supplies a potassium load, and diclofenac can reduce renal potassium excretion. In patients with renal impairment or other risk factors, hyperkalemia is possible, though the potassium amount in typical iodide doses is small.
What this interaction means in plain words
Diclofenac and Potassium iodide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Diclofenac belongs to Musculoskeletal; Potassium iodide belongs to Endocrine.
Why it happens
NSAID-induced suppression of renin-aldosterone axis and renal prostaglandins reduces potassium excretion, adding to potassium intake.
What to do
Monitor serum potassium in patients with renal impairment or on other potassium-raising drugs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Other interactions of Potassium iodide
- Amiloride + Potassium iodide Moderate
- Amlodipine-benazepril + Potassium iodide Moderate
- Amlodipine-hydrochlorothiazide-valsartan + Potassium iodide Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Potassium iodide Moderate
- Amlodipine-olmesartan + Potassium iodide Moderate
- Amlodipine-perindopril + Potassium iodide Moderate
Frequently asked questions
Can I take Diclofenac with Potassium iodide?
MediHelp rates the interaction as minor. Diclofenac and Potassium iodide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Potassium iodide supplies a potassium load, and diclofenac can reduce renal potassium excretion. In patients with renal impairment or other risk factors, hyperkalemia is possible, though the potassium amount in typical iodide doses is small.
How serious is the interaction between Diclofenac and Potassium iodide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium in patients with renal impairment or on other potassium-raising drugs.
What other medicines interact with Diclofenac?
MediHelp also lists interactions of Diclofenac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Diclofenac page.
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