Drug interactions
Diclofenac + Torsemide
Severity: Moderate
Diclofenac and Torsemide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diclofenac can blunt the diuretic and antihypertensive effect of torsemide by reducing renal prostaglandin synthesis, leading to sodium and fluid retention. In volume-depleted or older patients, the combination may also raise the risk of acute kidney injury.
What this interaction means in plain words
Diclofenac and Torsemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diclofenac belongs to Musculoskeletal; Torsemide belongs to Cardiovascular.
Why it happens
NSAID inhibition of renal prostaglandins reduces renal blood flow and natriuresis, antagonizing loop diuretic action.
What to do
Monitor blood pressure, weight, edema and renal function when starting or stopping diclofenac. Use the lowest effective NSAID dose for the shortest time and ensure adequate hydration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Other interactions of Torsemide
Frequently asked questions
Can I take Diclofenac with Torsemide?
MediHelp rates the interaction as moderate. Diclofenac and Torsemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diclofenac can blunt the diuretic and antihypertensive effect of torsemide by reducing renal prostaglandin synthesis, leading to sodium and fluid retention. In volume-depleted or older patients, the combination may also raise the risk of acute kidney injury.
How serious is the interaction between Diclofenac and Torsemide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, weight, edema and renal function when starting or stopping diclofenac. Use the lowest effective NSAID dose for the shortest time and ensure adequate hydration.
What other medicines interact with Diclofenac?
MediHelp also lists interactions of Diclofenac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Diclofenac page.
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