Drug interactions
Diclofenac + Voriconazole
Severity: Moderate
Diclofenac and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole inhibits CYP2C9, the main enzyme metabolizing diclofenac, and can increase diclofenac exposure. This raises the risk of NSAID adverse effects such as GI bleeding, renal impairment and cardiovascular events.
What this interaction means in plain words
Diclofenac and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diclofenac belongs to Musculoskeletal; Voriconazole belongs to Anti Fungals.
Why it happens
Inhibition of CYP2C9-mediated diclofenac metabolism by voriconazole.
What to do
Use the lowest effective diclofenac dose, and consider reducing the dose during voriconazole therapy. Monitor for NSAID toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Diclofenac with Voriconazole?
MediHelp rates the interaction as moderate. Diclofenac and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voriconazole inhibits CYP2C9, the main enzyme metabolizing diclofenac, and can increase diclofenac exposure. This raises the risk of NSAID adverse effects such as GI bleeding, renal impairment and cardiovascular events.
How serious is the interaction between Diclofenac and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective diclofenac dose, and consider reducing the dose during voriconazole therapy. Monitor for NSAID toxicity.
What other medicines interact with Diclofenac?
MediHelp also lists interactions of Diclofenac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Diclofenac page.
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