Drug interactions
Dicloxacillin + Fosinopril-hydrochlorothiazide
Severity: Minor
Dicloxacillin and Fosinopril-hydrochlorothiazide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazides and penicillins are both eliminated by renal tubular secretion, so competition might modestly raise levels of either. Any clinical effect is likely small and poorly documented.
What this interaction means in plain words
Dicloxacillin and Fosinopril-hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dicloxacillin belongs to Anti Bacterial; Fosinopril-hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Possible competition for renal tubular secretion via organic anion transporters.
What to do
No routine adjustment is needed; monitor for dicloxacillin adverse effects and electrolyte status during prolonged courses.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Other interactions of Dicloxacillin
- Dicloxacillin + Phenindione Major
- Atogepant + Dicloxacillin Moderate
- Axitinib + Dicloxacillin Moderate
- Bcg vaccine live + Dicloxacillin Moderate
- Cholera vaccine + Dicloxacillin Moderate
- Demeclocycline + Dicloxacillin Moderate
Frequently asked questions
Can I take Dicloxacillin with Fosinopril-hydrochlorothiazide?
MediHelp rates the interaction as minor. Dicloxacillin and Fosinopril-hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazides and penicillins are both eliminated by renal tubular secretion, so competition might modestly raise levels of either. Any clinical effect is likely small and poorly documented.
How serious is the interaction between Dicloxacillin and Fosinopril-hydrochlorothiazide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor for dicloxacillin adverse effects and electrolyte status during prolonged courses.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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