Drug interactions
Dicloxacillin + Tinidazole
Severity: Minor
Dicloxacillin and Tinidazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dicloxacillin is a weak CYP3A4 inducer and may modestly reduce tinidazole exposure, which is partly metabolised by CYP3A4. The clinical consequence is likely small, but it could reduce the effect of short-course antiprotozoal therapy.
What this interaction means in plain words
Dicloxacillin and Tinidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dicloxacillin belongs to Anti Bacterial; Tinidazole belongs to Anti Parasitic.
Why it happens
Dicloxacillin induces CYP3A4, which may increase the metabolism of tinidazole.
What to do
No routine adjustment is needed. Confirm clinical response to tinidazole and consider repeat dosing only if treatment appears to fail.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dicloxacillin and Tinidazole, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Dicloxacillin
- Dicloxacillin + Phenindione Major
- Atogepant + Dicloxacillin Moderate
- Axitinib + Dicloxacillin Moderate
- Bcg vaccine live + Dicloxacillin Moderate
- Cholera vaccine + Dicloxacillin Moderate
- Demeclocycline + Dicloxacillin Moderate
Other interactions of Tinidazole
- Disulfiram + Tinidazole Contraindicated
- Ethanol + Tinidazole Major
- Fexinidazole + Tinidazole Major
- Lopinavir + Tinidazole Major
- Nilotinib + Tinidazole Major
- Ritonavir + Tinidazole Major
Frequently asked questions
Can I take Dicloxacillin with Tinidazole?
MediHelp rates the interaction as minor. Dicloxacillin and Tinidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dicloxacillin is a weak CYP3A4 inducer and may modestly reduce tinidazole exposure, which is partly metabolised by CYP3A4. The clinical consequence is likely small, but it could reduce the effect of short-course antiprotozoal therapy.
How serious is the interaction between Dicloxacillin and Tinidazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Confirm clinical response to tinidazole and consider repeat dosing only if treatment appears to fail.
What other medicines interact with Dicloxacillin?
MediHelp also lists interactions of Dicloxacillin with, for example, Phenindione, Atogepant, Axitinib. The full list is on the Dicloxacillin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
