Drug interactions
Dicyclomine + Doxepin
Severity: Moderate
Dicyclomine and Doxepin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxepin, a tricyclic antidepressant, has strong antimuscarinic effects. Combined with dicyclomine, it can cause marked dry mouth, constipation, urinary retention, blurred vision, confusion and tachycardia.
What this interaction means in plain words
Dicyclomine and Doxepin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dicyclomine belongs to Respiratory; Doxepin belongs to Dermatology.
Why it happens
Additive muscarinic receptor blockade.
What to do
Monitor for anticholinergic toxicity, especially in older adults, and reduce doses or choose alternatives if symptoms appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dicyclomine
- Clozapine + Dicyclomine Major
- Dicyclomine + Henbane Major
- Dicyclomine + Imipramine Major
- Dicyclomine + Pramlintide Major
- Abobotulinumtoxina + Dicyclomine Moderate
- Aclidinium + Dicyclomine Moderate
Other interactions of Doxepin
- Doxepin + Isocarboxazid Contraindicated
- Doxepin + Phenelzine Contraindicated
- Doxepin + Procarbazine Contraindicated
- Doxepin + Safinamide Contraindicated
- Doxepin + Selegiline Contraindicated
- Doxepin + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Dicyclomine with Doxepin?
MediHelp rates the interaction as moderate. Dicyclomine and Doxepin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Doxepin, a tricyclic antidepressant, has strong antimuscarinic effects. Combined with dicyclomine, it can cause marked dry mouth, constipation, urinary retention, blurred vision, confusion and tachycardia.
How serious is the interaction between Dicyclomine and Doxepin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity, especially in older adults, and reduce doses or choose alternatives if symptoms appear.
What other medicines interact with Dicyclomine?
MediHelp also lists interactions of Dicyclomine with, for example, Clozapine, Henbane, Imipramine. The full list is on the Dicyclomine page.
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