Drug interactions
Dicyclomine + Ipratropium-salbutamol
Severity: Minor
Dicyclomine and Ipratropium-salbutamol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dicyclomine is an oral antimuscarinic and ipratropium is an inhaled antimuscarinic, so additive anticholinergic effects are theoretically possible. Systemic absorption of inhaled ipratropium is low, so the interaction is rarely clinically important at usual doses.
What this interaction means in plain words
Dicyclomine and Ipratropium-salbutamol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dicyclomine belongs to Respiratory; Ipratropium-salbutamol belongs to Respiratory.
Why it happens
Additive muscarinic receptor blockade, limited by minimal systemic absorption of inhaled ipratropium.
What to do
No dose change is usually required; monitor for dry mouth, constipation, urinary retention and blurred vision. Be more watchful in elderly patients and those with glaucoma or prostatic enlargement.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ipratropium-salbutamol
Other interactions of Dicyclomine
- Clozapine + Dicyclomine Major
- Dicyclomine + Henbane Major
- Dicyclomine + Imipramine Major
- Dicyclomine + Pramlintide Major
- Abobotulinumtoxina + Dicyclomine Moderate
- Aclidinium + Dicyclomine Moderate
Frequently asked questions
Can I take Dicyclomine with Ipratropium-salbutamol?
MediHelp rates the interaction as minor. Dicyclomine and Ipratropium-salbutamol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dicyclomine is an oral antimuscarinic and ipratropium is an inhaled antimuscarinic, so additive anticholinergic effects are theoretically possible. Systemic absorption of inhaled ipratropium is low, so the interaction is rarely clinically important at usual doses.
How serious is the interaction between Dicyclomine and Ipratropium-salbutamol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually required; monitor for dry mouth, constipation, urinary retention and blurred vision. Be more watchful in elderly patients and those with glaucoma or prostatic enlargement.
What other medicines interact with Ipratropium-salbutamol?
MediHelp also lists interactions of Ipratropium-salbutamol with, for example, Amisulpride, Arsenic trioxide, Carvedilol. The full list is on the Ipratropium-salbutamol page.
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