Drug interactions
Dicyclomine + Levodopa
Severity: Moderate
Dicyclomine and Levodopa: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Anticholinergics can complement levodopa in parkinsonism, but they may worsen dyskinesia and cause confusion or hallucinations in older patients. At higher doses they slow gastric emptying, which can delay or reduce levodopa absorption.
What this interaction means in plain words
Dicyclomine and Levodopa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dicyclomine belongs to Respiratory; Levodopa belongs to Central Nervous System.
Why it happens
Delayed gastric emptying reduces levodopa absorption, plus additive CNS anticholinergic effects.
What to do
Monitor motor response, dyskinesia and mental status; adjust levodopa timing or dose if the response becomes erratic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dicyclomine
- Clozapine + Dicyclomine Major
- Dicyclomine + Henbane Major
- Dicyclomine + Imipramine Major
- Dicyclomine + Pramlintide Major
- Abobotulinumtoxina + Dicyclomine Moderate
- Aclidinium + Dicyclomine Moderate
Other interactions of Levodopa
- Isocarboxazid + Levodopa Contraindicated
- Levodopa + Phenelzine Contraindicated
- Levodopa + Phenelzine (nonselective MAOI) Contraindicated
- Levodopa + Procarbazine Contraindicated
- Levodopa + Tranylcypromine Contraindicated
- Amisulpride + Levodopa Major
Frequently asked questions
Can I take Dicyclomine with Levodopa?
MediHelp rates the interaction as moderate. Dicyclomine and Levodopa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Anticholinergics can complement levodopa in parkinsonism, but they may worsen dyskinesia and cause confusion or hallucinations in older patients. At higher doses they slow gastric emptying, which can delay or reduce levodopa absorption.
How serious is the interaction between Dicyclomine and Levodopa?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor motor response, dyskinesia and mental status; adjust levodopa timing or dose if the response becomes erratic.
What other medicines interact with Dicyclomine?
MediHelp also lists interactions of Dicyclomine with, for example, Clozapine, Henbane, Imipramine. The full list is on the Dicyclomine page.
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