Drug interactions
Dicyclomine + Loxapine
Severity: Moderate
Dicyclomine and Loxapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Loxapine has anticholinergic effects, so added dicyclomine increases the risk of constipation, urinary retention, dry mouth, blurred vision and confusion. Reduced gut motility may also change oral absorption of loxapine.
What this interaction means in plain words
Dicyclomine and Loxapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dicyclomine belongs to Respiratory; Loxapine belongs to Central Nervous System.
Why it happens
Additive antimuscarinic effects with possible altered oral absorption from slowed GI motility.
What to do
Monitor for anticholinergic toxicity and for loss of antipsychotic effect. Prefer alternatives to dicyclomine in elderly or cognitively impaired patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dicyclomine
- Clozapine + Dicyclomine Major
- Dicyclomine + Henbane Major
- Dicyclomine + Imipramine Major
- Dicyclomine + Pramlintide Major
- Abobotulinumtoxina + Dicyclomine Moderate
- Aclidinium + Dicyclomine Moderate
Other interactions of Loxapine
- Alfentanil + Loxapine Major
- Alprazolam + Loxapine Major
- Amisulpride + Loxapine Major
- Amoxapine + Loxapine Major
- Apomorphine + Loxapine Major
- Belladonna and opium + Loxapine Major
Frequently asked questions
Can I take Dicyclomine with Loxapine?
MediHelp rates the interaction as moderate. Dicyclomine and Loxapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Loxapine has anticholinergic effects, so added dicyclomine increases the risk of constipation, urinary retention, dry mouth, blurred vision and confusion. Reduced gut motility may also change oral absorption of loxapine.
How serious is the interaction between Dicyclomine and Loxapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity and for loss of antipsychotic effect. Prefer alternatives to dicyclomine in elderly or cognitively impaired patients.
What other medicines interact with Dicyclomine?
MediHelp also lists interactions of Dicyclomine with, for example, Clozapine, Henbane, Imipramine. The full list is on the Dicyclomine page.
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