Drug interactions
Dicyclomine + Oliceridine
Severity: Moderate
Dicyclomine and Oliceridine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids slow gut motility and can cause urinary retention, and anticholinergics have the same effects. Together they raise the risk of severe constipation, paralytic ileus and urinary retention.
What this interaction means in plain words
Dicyclomine and Oliceridine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dicyclomine belongs to Respiratory; Oliceridine belongs to Musculoskeletal.
Why it happens
Additive reduction of gastrointestinal and bladder motility via opioid receptor agonism and muscarinic blockade.
What to do
Monitor bowel function and urinary output, and start a laxative regimen; stop the anticholinergic if ileus or retention develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dicyclomine and Oliceridine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Dicyclomine
- Clozapine + Dicyclomine Major
- Dicyclomine + Henbane Major
- Dicyclomine + Imipramine Major
- Dicyclomine + Pramlintide Major
- Abobotulinumtoxina + Dicyclomine Moderate
- Aclidinium + Dicyclomine Moderate
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Dicyclomine with Oliceridine?
MediHelp rates the interaction as moderate. Dicyclomine and Oliceridine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Opioids slow gut motility and can cause urinary retention, and anticholinergics have the same effects. Together they raise the risk of severe constipation, paralytic ileus and urinary retention.
How serious is the interaction between Dicyclomine and Oliceridine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor bowel function and urinary output, and start a laxative regimen; stop the anticholinergic if ileus or retention develops.
What other medicines interact with Dicyclomine?
MediHelp also lists interactions of Dicyclomine with, for example, Clozapine, Henbane, Imipramine. The full list is on the Dicyclomine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
