Drug interactions
Dicyclomine + Pilocarpine
Severity: Moderate
Dicyclomine and Pilocarpine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pilocarpine stimulates muscarinic receptors while dicyclomine blocks them, so they oppose one another. Pilocarpine's effects on salivation and sweating may be reduced.
What this interaction means in plain words
Dicyclomine and Pilocarpine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dicyclomine belongs to Respiratory; Pilocarpine belongs to Miscellaneous.
Why it happens
Pharmacodynamic antagonism between a muscarinic agonist and a muscarinic antagonist.
What to do
Monitor for loss of pilocarpine efficacy, such as persistent dry mouth. Avoid combining where possible, or adjust doses based on response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dicyclomine
- Clozapine + Dicyclomine Major
- Dicyclomine + Henbane Major
- Dicyclomine + Imipramine Major
- Dicyclomine + Pramlintide Major
- Abobotulinumtoxina + Dicyclomine Moderate
- Aclidinium + Dicyclomine Moderate
Other interactions of Pilocarpine
- Amitriptyline + Pilocarpine Moderate
- Atenolol-chlorthalidone + Pilocarpine Moderate
- Atenolol + Pilocarpine Moderate
- Atropine + Pilocarpine Moderate
- Betaxolol + Pilocarpine Moderate
- Bethanechol + Pilocarpine Moderate
Frequently asked questions
Can I take Dicyclomine with Pilocarpine?
MediHelp rates the interaction as moderate. Dicyclomine and Pilocarpine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pilocarpine stimulates muscarinic receptors while dicyclomine blocks them, so they oppose one another. Pilocarpine's effects on salivation and sweating may be reduced.
How serious is the interaction between Dicyclomine and Pilocarpine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of pilocarpine efficacy, such as persistent dry mouth. Avoid combining where possible, or adjust doses based on response.
What other medicines interact with Dicyclomine?
MediHelp also lists interactions of Dicyclomine with, for example, Clozapine, Henbane, Imipramine. The full list is on the Dicyclomine page.
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