Drug interactions
Dicyclomine + Quetiapine
Severity: Moderate
Dicyclomine and Quetiapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quetiapine's metabolite norquetiapine has anticholinergic activity, and the drug is sedating, so combined use increases anticholinergic and sedative effects. Constipation, urinary retention, dry mouth, tachycardia and confusion are the main concerns.
What this interaction means in plain words
Dicyclomine and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dicyclomine belongs to Respiratory; Quetiapine belongs to Central Nervous System.
Why it happens
Additive antimuscarinic effects with added sedation.
What to do
Monitor for constipation, urinary retention, sedation and delirium, particularly in older patients. Reduce dicyclomine or choose an alternative if effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dicyclomine
- Clozapine + Dicyclomine Major
- Dicyclomine + Henbane Major
- Dicyclomine + Imipramine Major
- Dicyclomine + Pramlintide Major
- Abobotulinumtoxina + Dicyclomine Moderate
- Aclidinium + Dicyclomine Moderate
Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Frequently asked questions
Can I take Dicyclomine with Quetiapine?
MediHelp rates the interaction as moderate. Dicyclomine and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quetiapine's metabolite norquetiapine has anticholinergic activity, and the drug is sedating, so combined use increases anticholinergic and sedative effects. Constipation, urinary retention, dry mouth, tachycardia and confusion are the main concerns.
How serious is the interaction between Dicyclomine and Quetiapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for constipation, urinary retention, sedation and delirium, particularly in older patients. Reduce dicyclomine or choose an alternative if effects emerge.
What other medicines interact with Dicyclomine?
MediHelp also lists interactions of Dicyclomine with, for example, Clozapine, Henbane, Imipramine. The full list is on the Dicyclomine page.
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