Drug interactions
Dicyclomine + Umeclidinium-vilanterol
Severity: Moderate
Dicyclomine and Umeclidinium-vilanterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dicyclomine is an antimuscarinic and can add to the anticholinergic effects of umeclidinium, including dry mouth, constipation, urinary retention and blurred vision. Systemic exposure from inhaled umeclidinium is low, so the interaction is usually manageable.
What this interaction means in plain words
Dicyclomine and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dicyclomine belongs to Respiratory; Umeclidinium-vilanterol belongs to Respiratory.
Why it happens
Additive antimuscarinic pharmacodynamic effects.
What to do
Monitor for urinary retention, constipation and visual symptoms, particularly in older adults or those with glaucoma or prostatic hypertrophy. Reduce or stop dicyclomine if symptoms arise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Umeclidinium-vilanterol
Other interactions of Dicyclomine
- Clozapine + Dicyclomine Major
- Dicyclomine + Henbane Major
- Dicyclomine + Imipramine Major
- Dicyclomine + Pramlintide Major
- Abobotulinumtoxina + Dicyclomine Moderate
- Aclidinium + Dicyclomine Moderate
Frequently asked questions
Can I take Dicyclomine with Umeclidinium-vilanterol?
MediHelp rates the interaction as moderate. Dicyclomine and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dicyclomine is an antimuscarinic and can add to the anticholinergic effects of umeclidinium, including dry mouth, constipation, urinary retention and blurred vision. Systemic exposure from inhaled umeclidinium is low, so the interaction is usually manageable.
How serious is the interaction between Dicyclomine and Umeclidinium-vilanterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for urinary retention, constipation and visual symptoms, particularly in older adults or those with glaucoma or prostatic hypertrophy. Reduce or stop dicyclomine if symptoms arise.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
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