Drug interactions
Didanosine + Levoketoconazole
Severity: Moderate
Didanosine and Levoketoconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole absorption depends on gastric acidity, and the antacid buffer in didanosine formulations can reduce it. This may lower cortisol-synthesis inhibition and efficacy.
What this interaction means in plain words
Didanosine and Levoketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Didanosine belongs to Anti Virals; Levoketoconazole belongs to Endocrine.
Why it happens
Buffered didanosine raises gastric pH, decreasing dissolution and absorption of levoketoconazole.
What to do
Give levoketoconazole at least 2 hours before buffered didanosine and monitor cortisol response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Didanosine
- Didanosine + Elvitegravir / cobicistat / emtricitabine / tenofovir df Contraindicated
- Didanosine + Hydroxycarbamide Contraindicated
- Didanosine + Ribavirin Contraindicated
- Didanosine + Stavudine Contraindicated
- Allopurinol + Didanosine Major
- Atidarsagene autotemcel + Didanosine Major
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Didanosine with Levoketoconazole?
MediHelp rates the interaction as moderate. Didanosine and Levoketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levoketoconazole absorption depends on gastric acidity, and the antacid buffer in didanosine formulations can reduce it. This may lower cortisol-synthesis inhibition and efficacy.
How serious is the interaction between Didanosine and Levoketoconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give levoketoconazole at least 2 hours before buffered didanosine and monitor cortisol response.
What other medicines interact with Didanosine?
MediHelp also lists interactions of Didanosine with, for example, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Hydroxycarbamide, Ribavirin. The full list is on the Didanosine page.
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