Drug interactions
Didanosine + Lopinavir
Severity: Minor
Didanosine and Lopinavir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lopinavir/ritonavir oral solution and didanosine have conflicting administration requirements: didanosine is taken fasting, while lopinavir/ritonavir is best taken with food. No clinically important pharmacokinetic interaction is established beyond timing.
What this interaction means in plain words
Didanosine and Lopinavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Didanosine belongs to Anti Virals; Lopinavir belongs to Anti Virals.
Why it happens
Conflicting food requirements rather than a direct pharmacokinetic interaction.
What to do
Give didanosine 1 hour before or 2 hours after lopinavir/ritonavir.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Didanosine
- Didanosine + Elvitegravir / cobicistat / emtricitabine / tenofovir df Contraindicated
- Didanosine + Hydroxycarbamide Contraindicated
- Didanosine + Ribavirin Contraindicated
- Didanosine + Stavudine Contraindicated
- Allopurinol + Didanosine Major
- Atidarsagene autotemcel + Didanosine Major
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
Frequently asked questions
Can I take Didanosine with Lopinavir?
MediHelp rates the interaction as minor. Didanosine and Lopinavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lopinavir/ritonavir oral solution and didanosine have conflicting administration requirements: didanosine is taken fasting, while lopinavir/ritonavir is best taken with food. No clinically important pharmacokinetic interaction is established beyond timing.
How serious is the interaction between Didanosine and Lopinavir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give didanosine 1 hour before or 2 hours after lopinavir/ritonavir.
What other medicines interact with Didanosine?
MediHelp also lists interactions of Didanosine with, for example, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Hydroxycarbamide, Ribavirin. The full list is on the Didanosine page.
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