Drug interactions
Dienogest / estradiol valerate + Posaconazole
Severity: Moderate
Dienogest / estradiol valerate and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole may raise exposure to both estradiol and dienogest, which are CYP3A4 substrates. This may cause estrogenic and progestogenic adverse effects such as breast tenderness, headache and irregular bleeding.
What this interaction means in plain words
Dienogest / estradiol valerate and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Posaconazole inhibits CYP3A4-mediated metabolism of dienogest and estradiol.
What to do
Monitor for hormone-related adverse effects, such as breast tenderness and irregular bleeding. Consider an alternative antifungal if these are troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Frequently asked questions
Can I take Dienogest / estradiol valerate with Posaconazole?
MediHelp rates the interaction as moderate. Dienogest / estradiol valerate and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Posaconazole may raise exposure to both estradiol and dienogest, which are CYP3A4 substrates. This may cause estrogenic and progestogenic adverse effects such as breast tenderness, headache and irregular bleeding.
How serious is the interaction between Dienogest / estradiol valerate and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for hormone-related adverse effects, such as breast tenderness and irregular bleeding. Consider an alternative antifungal if these are troublesome.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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