Drug interactions
Diethylpropion + Lisdexamfetamine
Severity: Major
Diethylpropion and Lisdexamfetamine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are sympathomimetic anorectic stimulants. Together they can cause additive increases in blood pressure and heart rate, with insomnia, anxiety and tachyarrhythmias. Duplicating stimulant therapy has no recognised benefit.
What this interaction means in plain words
Diethylpropion and Lisdexamfetamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive sympathomimetic effects through enhanced catecholamine release.
What to do
Avoid concurrent use. If unavoidable, monitor blood pressure, heart rate and cardiac symptoms.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Diethylpropion with Lisdexamfetamine?
MediHelp rates the interaction as major. Diethylpropion and Lisdexamfetamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both are sympathomimetic anorectic stimulants. Together they can cause additive increases in blood pressure and heart rate, with insomnia, anxiety and tachyarrhythmias. Duplicating stimulant therapy has no recognised benefit.
How serious is the interaction between Diethylpropion and Lisdexamfetamine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use. If unavoidable, monitor blood pressure, heart rate and cardiac symptoms.
What other medicines interact with Lisdexamfetamine?
MediHelp also lists interactions of Lisdexamfetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Lisdexamfetamine page.
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