Drug interactions
Difelikefalin + Fluoxetine
Severity: Minor
Difelikefalin and Fluoxetine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Difelikefalin, a kappa-opioid agonist, can cause somnolence and dizziness, and fluoxetine may add to sedation in some patients. The effect is generally mild to moderate.
What this interaction means in plain words
Difelikefalin and Fluoxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Difelikefalin belongs to Dermatology; Fluoxetine belongs to Central Nervous System.
Why it happens
Additive CNS-depressant effects.
What to do
Monitor for drowsiness, dizziness and fall risk, particularly in dialysis patients. No dose change is routinely needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Other interactions of Difelikefalin
- Acetazolamide + Difelikefalin Moderate
- Alprazolam + Difelikefalin Moderate
- Amantadine + Difelikefalin Moderate
- Amitriptyline + Difelikefalin Moderate
- Amobarbital + Difelikefalin Moderate
- Asenapine + Difelikefalin Moderate
Frequently asked questions
Can I take Difelikefalin with Fluoxetine?
MediHelp rates the interaction as minor. Difelikefalin and Fluoxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Difelikefalin, a kappa-opioid agonist, can cause somnolence and dizziness, and fluoxetine may add to sedation in some patients. The effect is generally mild to moderate.
How serious is the interaction between Difelikefalin and Fluoxetine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for drowsiness, dizziness and fall risk, particularly in dialysis patients. No dose change is routinely needed.
What other medicines interact with Fluoxetine?
MediHelp also lists interactions of Fluoxetine with, for example, Isocarboxazid, Mavacamten, Methylene blue. The full list is on the Fluoxetine page.
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