Drug interactions
Difelikefalin + Metaxalone
Severity: Moderate
Difelikefalin and Metaxalone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Difelikefalin can cause somnolence and dizziness, and metaxalone is also sedating. Using them together may increase drowsiness and impair alertness or coordination.
What this interaction means in plain words
Difelikefalin and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Difelikefalin belongs to Dermatology; Metaxalone belongs to Musculoskeletal.
Why it happens
Additive CNS depressant effects; difelikefalin is a peripherally restricted kappa-opioid agonist with some sedative adverse effects.
What to do
Monitor for increased drowsiness and dizziness, particularly at initiation, and counsel patients about activities requiring alertness. Reduce a dose if sedation becomes troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metaxalone
Other interactions of Difelikefalin
- Acetazolamide + Difelikefalin Moderate
- Alprazolam + Difelikefalin Moderate
- Amantadine + Difelikefalin Moderate
- Amitriptyline + Difelikefalin Moderate
- Amobarbital + Difelikefalin Moderate
- Asenapine + Difelikefalin Moderate
Frequently asked questions
Can I take Difelikefalin with Metaxalone?
MediHelp rates the interaction as moderate. Difelikefalin and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Difelikefalin can cause somnolence and dizziness, and metaxalone is also sedating. Using them together may increase drowsiness and impair alertness or coordination.
How serious is the interaction between Difelikefalin and Metaxalone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased drowsiness and dizziness, particularly at initiation, and counsel patients about activities requiring alertness. Reduce a dose if sedation becomes troublesome.
What other medicines interact with Metaxalone?
MediHelp also lists interactions of Metaxalone with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Metaxalone page.
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