Drug interactions
Difenoxin + Prochlorperazine
Severity: Moderate
Difenoxin and Prochlorperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Difenoxin is an opioid antidiarrheal metabolite and can cause drowsiness at higher doses. With prochlorperazine, sedation and CNS depression may be increased.
What this interaction means in plain words
Difenoxin and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Difenoxin belongs to Gastrointestinal Tract; Prochlorperazine belongs to Central Nervous System.
Why it happens
Additive CNS depression from opioid-receptor agonism and phenothiazine effects.
What to do
Monitor for excessive drowsiness and avoid exceeding recommended doses. Caution patients about driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Difenoxin
Frequently asked questions
Can I take Difenoxin with Prochlorperazine?
MediHelp rates the interaction as moderate. Difenoxin and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Difenoxin is an opioid antidiarrheal metabolite and can cause drowsiness at higher doses. With prochlorperazine, sedation and CNS depression may be increased.
How serious is the interaction between Difenoxin and Prochlorperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive drowsiness and avoid exceeding recommended doses. Caution patients about driving.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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