Drug interactions
Diflunisal + Ephedrine
Severity: Minor
Diflunisal and Ephedrine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may modestly alter the blood pressure response to sympathomimetics, and the potassium effects are small and unpredictable. No significant clinically established interaction exists.
What this interaction means in plain words
Diflunisal and Ephedrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Diflunisal belongs to Musculoskeletal; Ephedrine belongs to Cardiovascular.
Why it happens
Mechanism not well established; ephedrine causes beta-2 mediated potassium shift while NSAIDs may reduce renal potassium excretion.
What to do
No routine action beyond monitoring blood pressure; check potassium if the patient has renal impairment or other risk factors.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Other interactions of Ephedrine
- Ephedrine + Isocarboxazid Contraindicated
- Ephedrine + Phenelzine Contraindicated
- Ephedrine + Procarbazine Contraindicated
- Ephedrine + Rasagiline Contraindicated
- Ephedrine + Selegiline Contraindicated
- Ephedrine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Diflunisal with Ephedrine?
MediHelp rates the interaction as minor. Diflunisal and Ephedrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. NSAIDs may modestly alter the blood pressure response to sympathomimetics, and the potassium effects are small and unpredictable. No significant clinically established interaction exists.
How serious is the interaction between Diflunisal and Ephedrine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action beyond monitoring blood pressure; check potassium if the patient has renal impairment or other risk factors.
What other medicines interact with Diflunisal?
MediHelp also lists interactions of Diflunisal with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Diflunisal page.
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