Drug interactions
Diflunisal + Eplerenone
Severity: Moderate
Diflunisal and Eplerenone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can weaken the antihypertensive effect of eplerenone and, in combination, increase the risk of hyperkalemia and renal impairment. The risk is higher in older, volume-depleted or renally impaired patients.
What this interaction means in plain words
Diflunisal and Eplerenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diflunisal belongs to Musculoskeletal; Eplerenone belongs to Cardiovascular.
Why it happens
NSAID inhibition of renal prostaglandin synthesis causes sodium and fluid retention and reduces renal potassium excretion, opposing and compounding eplerenone's effects.
What to do
Monitor blood pressure, serum potassium and creatinine when diflunisal is added or used regularly, and avoid it in patients with renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Other interactions of Eplerenone
- Amiloride + Eplerenone Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Clarithromycin + Eplerenone Contraindicated
- Cobicistat + Eplerenone Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Eplerenone Contraindicated
- Ensitrelvir + Eplerenone Contraindicated
Frequently asked questions
Can I take Diflunisal with Eplerenone?
MediHelp rates the interaction as moderate. Diflunisal and Eplerenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can weaken the antihypertensive effect of eplerenone and, in combination, increase the risk of hyperkalemia and renal impairment. The risk is higher in older, volume-depleted or renally impaired patients.
How serious is the interaction between Diflunisal and Eplerenone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum potassium and creatinine when diflunisal is added or used regularly, and avoid it in patients with renal impairment.
What other medicines interact with Diflunisal?
MediHelp also lists interactions of Diflunisal with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Diflunisal page.
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