Drug interactions
Diflunisal + Ethacrynic acid
Severity: Moderate
Diflunisal and Ethacrynic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce the diuretic and natriuretic response to loop diuretics and raise the risk of acute kidney injury, particularly in volume-depleted patients. Potassium effects are variable.
What this interaction means in plain words
Diflunisal and Ethacrynic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diflunisal belongs to Musculoskeletal; Ethacrynic acid belongs to Cardiovascular.
Why it happens
NSAID inhibition of renal prostaglandins reduces renal blood flow and sodium excretion, antagonizing the loop diuretic effect.
What to do
Monitor diuretic response, weight, renal function and electrolytes. Use the lowest effective NSAID dose or an alternative analgesic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Other interactions of Ethacrynic acid
Frequently asked questions
Can I take Diflunisal with Ethacrynic acid?
MediHelp rates the interaction as moderate. Diflunisal and Ethacrynic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can reduce the diuretic and natriuretic response to loop diuretics and raise the risk of acute kidney injury, particularly in volume-depleted patients. Potassium effects are variable.
How serious is the interaction between Diflunisal and Ethacrynic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor diuretic response, weight, renal function and electrolytes. Use the lowest effective NSAID dose or an alternative analgesic.
What other medicines interact with Diflunisal?
MediHelp also lists interactions of Diflunisal with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Diflunisal page.
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