Drug interactions
Diflunisal + Gemifloxacin
Severity: Moderate
Diflunisal and Gemifloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs given with fluoroquinolones may increase the risk of CNS stimulation and convulsions, particularly in patients with epilepsy or other seizure risk factors. The effect is uncommon but can be serious.
What this interaction means in plain words
Diflunisal and Gemifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diflunisal belongs to Musculoskeletal; Gemifloxacin belongs to Anti Bacterial.
Why it happens
Fluoroquinolones antagonize GABA-A receptors and NSAIDs may potentiate this effect; the mechanism is not fully established.
What to do
Avoid the combination in patients with seizure disorders or a lowered seizure threshold; otherwise counsel patients to report tremor, agitation or confusion and stop the fluoroquinolone if neurologic symptoms appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Other interactions of Gemifloxacin
- Arsenic trioxide + Gemifloxacin Contraindicated
- Dofetilide + Gemifloxacin Contraindicated
- Gemifloxacin + Ibutilide Contraindicated
- Gemifloxacin + Pimozide Contraindicated
- Gemifloxacin + Thioridazine Contraindicated
- Gemifloxacin + Vandetanib Contraindicated
Frequently asked questions
Can I take Diflunisal with Gemifloxacin?
MediHelp rates the interaction as moderate. Diflunisal and Gemifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs given with fluoroquinolones may increase the risk of CNS stimulation and convulsions, particularly in patients with epilepsy or other seizure risk factors. The effect is uncommon but can be serious.
How serious is the interaction between Diflunisal and Gemifloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in patients with seizure disorders or a lowered seizure threshold; otherwise counsel patients to report tremor, agitation or confusion and stop the fluoroquinolone if neurologic symptoms appear.
What other medicines interact with Diflunisal?
MediHelp also lists interactions of Diflunisal with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Diflunisal page.
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