Drug interactions
Diflunisal + Gentamicin
Severity: Moderate
Diflunisal and Gentamicin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce renal function and may raise gentamicin serum concentrations, especially in neonates, older patients and those who are dehydrated. This increases the risk of nephrotoxicity and ototoxicity.
What this interaction means in plain words
Diflunisal and Gentamicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diflunisal belongs to Musculoskeletal; Gentamicin belongs to Anti Bacterial.
Why it happens
NSAID-related reduction in renal prostaglandins and glomerular filtration decreases gentamicin clearance, adding to aminoglycoside nephrotoxicity.
What to do
Monitor serum creatinine and gentamicin trough levels, ensure adequate hydration, and adjust the gentamicin dose accordingly. Consider an alternative analgesic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Other interactions of Gentamicin
- Cidofovir + Gentamicin Contraindicated
- Adefovir + Gentamicin Major
- Amikacin + Gentamicin Major
- Amlodipine-hydrochlorothiazide-valsartan + Gentamicin Major
- Amphotericin b deoxycholate + Gentamicin Major
- Amphotericin b + Gentamicin Major
Frequently asked questions
Can I take Diflunisal with Gentamicin?
MediHelp rates the interaction as moderate. Diflunisal and Gentamicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can reduce renal function and may raise gentamicin serum concentrations, especially in neonates, older patients and those who are dehydrated. This increases the risk of nephrotoxicity and ototoxicity.
How serious is the interaction between Diflunisal and Gentamicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and gentamicin trough levels, ensure adequate hydration, and adjust the gentamicin dose accordingly. Consider an alternative analgesic.
What other medicines interact with Diflunisal?
MediHelp also lists interactions of Diflunisal with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Diflunisal page.
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