Drug interactions
Diflunisal + Imidapril
Severity: Moderate
Diflunisal and Imidapril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diflunisal can blunt the blood pressure lowering effect of imidapril. In patients who are volume depleted, elderly or have reduced kidney function, the combination may also increase the risk of acute kidney injury and hyperkalemia.
What this interaction means in plain words
Diflunisal and Imidapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diflunisal belongs to Musculoskeletal; Imidapril belongs to Cardiovascular.
Why it happens
NSAID inhibition of renal prostaglandin synthesis reduces vasodilation and sodium excretion, opposing ACE inhibitor effects and impairing glomerular perfusion.
What to do
Monitor blood pressure, serum creatinine and potassium when starting or stopping diflunisal in a patient taking imidapril. Keep the NSAID course short and make sure the patient is well hydrated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Other interactions of Imidapril
- Amiloride + Imidapril Major
- Eplerenone + Imidapril Major
- Imidapril + Lithium Major
- Imidapril + Pregabalin Major
- Imidapril + Spironolactone Major
- Imidapril + Triamterene Major
Frequently asked questions
Can I take Diflunisal with Imidapril?
MediHelp rates the interaction as moderate. Diflunisal and Imidapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diflunisal can blunt the blood pressure lowering effect of imidapril. In patients who are volume depleted, elderly or have reduced kidney function, the combination may also increase the risk of acute kidney injury and hyperkalemia.
How serious is the interaction between Diflunisal and Imidapril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium when starting or stopping diflunisal in a patient taking imidapril. Keep the NSAID course short and make sure the patient is well hydrated.
What other medicines interact with Diflunisal?
MediHelp also lists interactions of Diflunisal with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Diflunisal page.
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