Drug interactions
Diflunisal + Labetalol
Severity: Moderate
Diflunisal and Labetalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce the blood pressure lowering effect of beta-blockers such as labetalol, particularly with prolonged use.
What this interaction means in plain words
Diflunisal and Labetalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diflunisal belongs to Musculoskeletal; Labetalol belongs to Cardiovascular.
Why it happens
Inhibition of vasodilatory prostaglandins and sodium and water retention oppose the antihypertensive effect.
What to do
Monitor blood pressure during concurrent use and adjust labetalol dose if control worsens. Limit NSAID dose and duration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Frequently asked questions
Can I take Diflunisal with Labetalol?
MediHelp rates the interaction as moderate. Diflunisal and Labetalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can reduce the blood pressure lowering effect of beta-blockers such as labetalol, particularly with prolonged use.
How serious is the interaction between Diflunisal and Labetalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure during concurrent use and adjust labetalol dose if control worsens. Limit NSAID dose and duration.
What other medicines interact with Diflunisal?
MediHelp also lists interactions of Diflunisal with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Diflunisal page.
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